12 Whether these problems were caused by chromium picolinate or, if so, whether other forms of chromium might have the same effects at these high amounts remains unclear. 11 A case of a muscle disease known as rhabdomyolysis appeared in a body builder who took 1200 mcg over 48 hours. 10 A case of anemia, liver dysfunction, and other problems appeared after four to five months of 1,200–2,400 mcg per day. A case of kidney failure appeared after taking 600 mcg per day for six weeks. Three single, unrelated cases of toxicity have been reported from use of chromium picolinate. 9 However, no published evidence supports this assertion. Another source claimed that there have been reports of mild heart rhythm abnormalities with excessive chromium ingestion. 8 However, chromium supplementation was not proven to be the cause of these problems. One report of severe illness (including liver and kidney damage) occurring in a person who was taking 1,000 mcg of chromium per day has been reported. 6 In theory, these changes could increase the risk of cancer, but so far, chromium intake has not been linked to increased incidence of cancer in humans. 4, 5 Chromium picolinate can be altered by antioxidants or hydrogen peroxide in the body to a form that could itself create free radical damage. One study suggested that chromium in very high concentrations in a test tube could cause chromosomal mutations in ovarian cells of hamsters. While there are a few reports of people developing medical problems while taking chromium, a cause-effect relationship was not proven. In supplemental amounts (typically 50–300 mcg per day), chromium has not been found to cause toxicity in humans.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |